Skip to main content
Knowledge4Policy
Knowledge4Policy (K4P)

Toxic Dependency: How Agrochemicals Lock In Food System Vulnerability

  • Publication | 2026

Highlights:

Drawing on contributions from twenty-nine expert partners, including researchers, farmer movements, Indigenous organizations, and civil society networks from around the globe, this compendium:

• Maps the system: Traces how fossil fuel dependence flows through agrochemical production to commodity crop production, industrial livestock, ultra-processed foods, and biofuels—and back again—in a self-reinforcing cycle.

• Aggregates the evidence and documents the true costs: Brings together evidence on the environmental costs; the health costs; and the social costs (including farmer debt, eroded sovereignty, and chemical dependency).

• Identifies the lock-ins: Examines the corporate concentration, technology treadmill, policy and subsidy structures, and legitimising narratives that perpetuate this system despite mounting evidence of its harm.

• Charts four interconnected pathways for change: Identifies opportunities for funders and partners to align strategies that expand the evidence base and reframe narratives; align policy, regulation, and finance; rebalance power and foster accountability; and create enabling conditions for agrochemical transitions.

In this compendium, the authors explore the importance of moving toward food production practices that reduce or fully eliminate the reliance on synthetic nitrogen fertiliser and synthetic pesticides. These practices range from bringing regenerative practices to monoculture production to adopting certified organic agriculture in regions where organic is codified to using agroecological practices as defined by the 13 principles of agroecology.

Key figures on the true costs of agrochemical products

The document synthesises information from a range of sources to better inform about the hidden costs of modern agricultural systems. The report highlights figures showing where economic outputs from chemical agriculture mask the true costs that agrochemical products create in local and territorial markets.  

In 2024, the FAO estimated through the State of Food and Agriculture (SOFA) report that the global hidden costs of agri-food systems exceeded 10 trillion US dollars annually.  

The report cites recent expert work, according to which pesticide exposure triggers global human health costs of 816 billion US dollars per year. In an illustrative example the study points to evidence from Nepal, where the cost of pesticide-related illness for farmers due to pesticide use was nearly one-third of total annual healthcare costs.  

From an environmental perspective, FAO estimates that primary-level nitrogen emissions – encompassing atmospheric pollution from ammonia and nitrogen oxide, water leaching, run-off, and sewage – generate annual global environmental damages exceeding 1.45 trillion US dollars. 

The report argues that by using True Cost Accounting and holding polluters financially accountable, the hidden costs can be exposed in order to stop funding models that shift health, environmental, and social damages onto society. 

Related reading
ONLINE RESOURCE | 19 Oct 2026
EU Food System Monitoring Dashboard
The EU Food System Dashboard is a tool developed by the European Commission’s Joint Research Centre (JRC) to monitor the sustainability of the EU food system from an environmental, economic and social...
Privacy statements, terms and conditions.
You will be directed to the EU Login website where you can login/register as a user. Once connected, your credentials (First name, last name, username, email) will be registered in Knowledge4policy as part of your profile, which will allow you to get involved in all Knowledge4policy communities (help is available).

You are about to navigate to an external website. Please note that we are not responsible for its content.